I've nearly always used Debian and Ubuntu, but went through a 2 year phase of using Fedora. I find Ubuntu's setup very simple in comparison - much simpler than other distros I've used. I picked it up with hardly any reading, but the drawback is that when you come to another system (we use CentOS in our office, so I get confused when I can't find the configs!). Both "systems" have advantages and disadvantages, but simply doing a2enmod/a2ensite to enable a site is pure gold in my opinion. Nice write-up, gives a good summary of the differences.