This year I moved my whole presentations toolchain over to LaTeX and PDF, and where I added diagrams (which doesn't happen a lot!) I used graphviz to generate them. Graphviz is a way of describing items and their relationships in a textual manner, and rendering them into a graph - and the results can be saved as an image, or included in LaTeX documents.
I found graphviz frustrating at times but on the whole it draws clean, symmetrical graphs far beyond anything else I can manage, even if I do use a mouse or tablet. Since I'm not able to use a pointing device on a regular basis, and I'm marking up my presentations in text also, it turned out to be a really good fit. I thought I'd share how I got on with it and some of my own graphs - as much to remind me next time conference season comes around as anything.